Title:
Regulation of the ghrelin level which uses non-acylating ghrelin, and ghrelin / non-acylating ghrelin ratio
Document Type and Number:
Japanese Patent JP6031121
Kind Code:
B2
Abstract:
A method and a composition for decreasing ghrelin levels and/or decreasing ghrelin/unacylated ghrelin ratio in a subject, the method comprising administering an effective amount of unacylated ghrelin, a fragment thereof, an analog thereof and/or pharmaceutically acceptable salts thereof to the subject wherein a reduction in ghrelin levels and/or a reduction in ghrelin/unacylated ghrelin ratio is beneficial to the subject. Also, use of ghrelin level and/or ghrelin/unacylated ghrelin ratio as biomarkers for determining a subject's likelihood of responding to and/or benefiting from administration of unacylated ghrelin.
Inventors:
Van der rery, art yang
Abrivato, Thierry
Abrivato, Thierry
Application Number:
JP2014546665A
Publication Date:
November 24, 2016
Filing Date:
December 14, 2012
Export Citation:
Assignee:
Alize Pharma SRS
International Classes:
A61K38/00; A61K38/08; A61P3/04; A61P3/06; A61P3/10
Domestic Patent References:
| JP2010528092A | ||||
| JP2011522864A |
Foreign References:
| EP2067481A1 |
Other References:
Inhoff, T. et al.,Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats,Peptides,2008年,29巻12号,pp. 2159-2168.
Cummings, D. E. et al.,Elevated plasma ghrelin levels in Prader-Wili syndrome,Nature Med.,2002年,8巻7号,pp. 643-644.
Cummings, D. E. et al.,Elevated plasma ghrelin levels in Prader-Wili syndrome,Nature Med.,2002年,8巻7号,pp. 643-644.
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Nozomi Murabayashi
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Nozomi Murabayashi
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