Title:
ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節
Document Type and Number:
Japanese Patent JP5374162
Kind Code:
B2
Abstract:
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
Inventors:
Miller, Guy M.
Hector, Sidney M.
Jankoski, Orion Dee.
Wesson, Kieron Yi.
Morard, paul
Hector, Sidney M.
Jankoski, Orion Dee.
Wesson, Kieron Yi.
Morard, paul
Application Number:
JP2008556437A
Publication Date:
December 25, 2013
Filing Date:
February 22, 2007
Export Citation:
Assignee:
Edison Pharmaceuticals, Inc.
International Classes:
C07C43/225; C07C43/295; C07C47/277; C07C50/02; C07C50/06; C07C50/28; C07C69/145; C07C233/22; C07C233/31; C07C255/37; A61K31/05; A61K31/122; A61P3/10; A61P3/12; A61P7/00; A61P9/00; A61P11/00; A61P13/02; A61P21/00; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P35/00; A61P43/00
Foreign References:
| US20050065099 |
Other References:
Biochemical Pharmacology,2005年,70,pp.1361-1370
FEBS Letters,1999年,446,pp.1-5
Ukrainian Biochemical Journal ,2003年,75,pp.67-71
The FASEB Journal,2003年,17,pp.1972-1974
Tetrahedron,1998年,54,pp.1241-1253
Annals of the New York Academy of Sciences,2004年,pp.341-343
BiochemicalPharmacology,2004年,68,pp.373-381
Free Radical Biology & Medicine,2001年,30,pp.865-876
The Journal of Biological Chemistry,2000年,22,pp.29521-29527
FEBS Letters,1999年,446,pp.1-5
Ukrainian Biochemical Journal ,2003年,75,pp.67-71
The FASEB Journal,2003年,17,pp.1972-1974
Tetrahedron,1998年,54,pp.1241-1253
Annals of the New York Academy of Sciences,2004年,pp.341-343
BiochemicalPharmacology,2004年,68,pp.373-381
Free Radical Biology & Medicine,2001年,30,pp.865-876
The Journal of Biological Chemistry,2000年,22,pp.29521-29527
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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