Title:
調節物質
Document Type and Number:
Japanese Patent JP4925834
Kind Code:
B2
Abstract:
The present invention relates to a compound of formula I, or a pharmaceutically acceptable salt thereof,
wherein Z is OR 1 or NR 1 R 2 wherein each of R 1 and R 2 is independently H, or a hydrocarbyl group;X is an alkylene, alkenylene, or alkynylene group, each of which may be optionally substituted by one or more substituents selected from alkyl, COOH, CO 2 -alkyl, alkenyl, CN, NH 2 , hydroxy, halo, alkoxy, CF 3 and nitro;
Y is a polar functional group selected from OH, NO 2 CN, COR 3 , COOR 3 , NR 3 R 4 , CONR 3 R 4 , SO 3 H, SO 2 -R 3 , SO 2 NR 3 R 4 and CF 3 , where each of R 3 and R 4 is independently H or a hydrocarbyl group;
A is an aryl or heteroaryl group, each of which may be optionally substituted; and
B is (CH 2 ) n where n is 0, 1, 2, 3, 4 or 5;
with the proviso that:
(i) when A is phenyl, n is 0, and Z is OH, X-Y is other than meta -C¡C-(CH 2 ) 2 CO 2 H, meta -C¡C-(CH 2 ) 2 OH, meta -C¡C-(CH 2 ) 2 CO 2 Me, meta- (CH 2 ) 4 CO 2 H, ortho -CH 2 CO 2 H, ortho -(CH 2 ) 2 CO 2 H and ortho -(CH 2 ) 4 CO 2 H; and
(ii) when A is phenyl, n is 0, and Z is OMe, X-Y is other than meta -C¡C-(CH 2 ) 4 OH. Further aspects of the invention relate to the use of such compounds in the preparation of a medicament for the treatment of a muscular disorder, a gastrointestinal disorder, or for controlling spasticity or tremors.
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Inventors:
Masahiro Okuyama
Selwood david
Byzantine Christina
Baker david
Price Gareth
Selwood david
Byzantine Christina
Baker david
Price Gareth
Application Number:
JP2006553673A
Publication Date:
May 09, 2012
Filing Date:
February 21, 2005
Export Citation:
Assignee:
ULC Business PLC
International Classes:
C07C233/65; A61K31/166; A61K31/195; A61K31/216; A61K31/235; A61K31/277; A61P1/00; A61P1/04; A61P1/12; A61P21/00; A61P25/00; A61P37/02; A61P43/00; C07C63/04; C07C69/76; C07C69/78; C07C233/11; C07C233/66; C07C233/68; C07C233/69; C07C233/77; C07C235/42; C07C235/78; C07C235/84; C07C237/32; C07C237/38; C07C237/42; C07C255/41; G01N33/15; G01N33/50
Domestic Patent References:
| JP2001513529A | ||||
| JP1316363A | ||||
| JP2005527586A | ||||
| JP2004502642A |
Foreign References:
| WO2003091204A1 | ||||
| GB2196629A | ||||
| WO1997029079A1 |
Other References:
Organic Letters,2002年,4(10),p.1807-1808
Drug Design and Discovery,2000年,16(4),p.281-294
Tetrahedron Letters,1998年,39(47),p.8563-8566
Drug Design and Discovery,2000年,16(4),p.281-294
Tetrahedron Letters,1998年,39(47),p.8563-8566
Attorney, Agent or Firm:
Masaki Hirota