Title:
放出制御錠剤
Document Type and Number:
Japanese Patent JP5427677
Kind Code:
B2
Abstract:
Metformin or a pharmaceutically acceptable salt thereof for use in providing continuous and non-pulsating plasma levels of an antihyperglycemic drug with a peak plasma level within 8-12 hours after administration when administered with or shortly after the evening meal in a controlled release pharmaceutical tablet exhibiting the following dissolution profile when tested in a USP type 2 apparatus at 75 rpm in 900 ml of simulated intestinal fluid (pH 7.5 phosphate buffer) and at 37 °C:
- after 2 hours 0-25% of the drug is released;
- after 4 hours 10-45% of the drug is released;
- after 8 hours 30-90% of the drug is released;
- after 12 hours not less than 50% of the drug is released;
- after 16 hours not less than 60% of the drug is released; and
- after 20 hours not less than 70% of the drug is released.
Inventors:
Cheng, Jiu Jiu
Chen, Chi-ming
Jean, Steve
Butterfly, joseph
Chen, Chi-ming
Jean, Steve
Butterfly, joseph
Application Number:
JP2010090641A
Publication Date:
February 26, 2014
Filing Date:
April 09, 2010
Export Citation:
Assignee:
Andlux Pharmaceuticals, Inc.
International Classes:
A61K31/155; A61K9/00; A61K9/20; A61K9/22; A61K9/28; A61K9/52; A61K47/02; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/26; A61K47/32; A61K47/34; A61K47/38; A61K47/44; A61P3/10
Domestic Patent References:
| JP8092088A |
Foreign References:
| WO1996008243A1 | ||||
| WO1996040080A1 | ||||
| WO1995028963A1 | ||||
| WO1997005903A1 |
Attorney, Agent or Firm:
Kimura Mitsuru
Takuji Harada
Takanori Mamoru
Taiji Morikawa
Amamiya Yasuhito
Kei Sakurada
Mie Hideki
Takuji Harada
Takanori Mamoru
Taiji Morikawa
Amamiya Yasuhito
Kei Sakurada
Mie Hideki