Title:
REOVIRUS CLEARANCE OF RAS-MEDIATED NEOPLASTIC CELL FROM MIXED CELLULAR COMPOSITION
Document Type and Number:
Japanese Patent JP2008278897
Kind Code:
A
Abstract:
To provide a very selective method that attains a considerable yield for purifying autograft that possibly includes neoplastic cells.
The invention relates to a method for removing ras-mediated neoplastic cells from a mixed cellular composition by infecting the mixed cellular composition with a reovirus that selectively infect and kill ras-mediated neoplastic cells. Since a variety of viruses relate to the activated ras route, this invention can be used for removing mixed, autogenetic neoplastic cells from a large range of mixed cellular compositions.
Inventors:
MORRIS DONALD
THOMPSON BRADLEY G
COFFEY MATTHEW C
THOMPSON BRADLEY G
COFFEY MATTHEW C
Application Number:
JP2008190310A
Publication Date:
November 20, 2008
Filing Date:
July 23, 2008
Export Citation:
Assignee:
ONCOLYTICS BIOTECH INC
International Classes:
C12N7/00; A61K35/23; A61K35/28; A61K35/36; A61K35/39; A61K35/407; A61K35/42; A61K35/52; A61K35/54; A61K35/76; A61K35/765; A61K48/00; A61L2/00; A61L27/00; A61P43/00; C12N5/00; C12N5/09; C12N15/861; A61K35/12
Foreign References:
| WO1999008692A1 | 1999-02-25 |
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
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