Title:
Replacement therapy for rodents
Document Type and Number:
Japanese Patent JP6297506
Kind Code:
B2
Abstract:
The invention provides improvements of lantibiotics useful for reducing the numbers of microbes or the reproduction of microbes in or on subjects or objects. One embodiment of the invention provides variants of MU1140 wherein the amino acid at position (1) is changed to Gly, the amino acid at position (4) is changed to an Ala, or the amino acid at position (13) is substituted with Asp, or combinations of two or more these changes or a pharmaceutically acceptable salt thereof.
Inventors:
Jeffrey Di Hillman
James Rafe Smith
Shawanda Earl Wilson-Stamford
James Rafe Smith
Shawanda Earl Wilson-Stamford
Application Number:
JP2014558872A
Publication Date:
March 20, 2018
Filing Date:
February 22, 2013
Export Citation:
Assignee:
Orangeix, Incorporated
International Classes:
C12N1/21; A01N63/20; A61K35/74; A61P1/02; C12N15/09
Domestic Patent References:
| JP2009028050A | ||||
| JP2002504825A | ||||
| JP11500604A |
Foreign References:
| WO2009135945A1 | ||||
| WO2010117652A1 |
Other References:
International Journal of Clinical Pediatric Dentistry,2010年,Vol.3, No.3,p.125-137
Infection and Immunity,2000年,Vol.68, No.2,p.543-549
Infection and Immunity,2000年,Vol.68, No.2,p.543-549
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Fumio Inai
Manami Sasakura
Hiroshi Yamazaki
Kenji Tomita
Fumio Inai
Manami Sasakura