Title:
REPROGRAMMING OF SOMATIC CELLS
Document Type and Number:
Japanese Patent JP2015051022
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a reprogramming of somatic cells.SOLUTION: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments, the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of the cells, and to methods for identifying agents useful for reprogramming somatic cells. The present invention provides engineered somatic cells, in which one or more endogenous pluripotency gene is operably linked to a selectable marker in such a manner that the expression of the selectable marker substantially matches the expression of the endogenous pluripotency gene to which the marker is linked.
Inventors:
RUDOLF JAENISCH
JACOB HANNA
MARIUS WERNIG
CHRISTOPHER J LENGNER
ALEXANDER MEISSNER
OLIVER TOBIAS BRAMBRINK
G GRANT WELSTEAD
RUTH FOREMAN
JACOB HANNA
MARIUS WERNIG
CHRISTOPHER J LENGNER
ALEXANDER MEISSNER
OLIVER TOBIAS BRAMBRINK
G GRANT WELSTEAD
RUTH FOREMAN
Application Number:
JP2014251545A
Publication Date:
March 19, 2015
Filing Date:
December 12, 2014
Export Citation:
Assignee:
WHITEHEAD BIOMEDICAL INST
International Classes:
C12Q1/68; C12N5/071; C12N5/10; C12N15/09; C12N15/113; C12Q1/02; C12Q1/04; C12Q1/42; C12Q1/48; G01N33/15; G01N33/48; G01N33/50
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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