残留溶媒抽出方法および同により生成される微粒子 - Arcams Controlled Therapeutics, Incorporated Two

Title:

残留溶媒抽出方法および同により生成される微粒子

Document Type and Number:

Japanese Patent JP2005502674

Kind Code:

A

Abstract:

Methods for preparing microparticles having reduced residual solvent levels are disclosed. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.

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Inventors:

Ricky, Michael, Yi.
Ram Stack, J., Michael
Kumar, Rajesh

Application Number:

JP2003524554A

Publication Date:

January 27, 2005

Filing Date:

August 26, 2002

Export Citation:

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Assignee:

Arcams Controlled Therapeutics, Incorporated Two

International Classes:

A61K9/16; A61K31/519; A61K38/00; A61K38/04; A61K47/32; A61K47/34; B65D5/462; B01J8/02; B01J13/08; B01J13/12; B01J13/20; B01J14/00; B01J19/12; B01J19/24; B65D5/46; B65D5/465; B65D71/00; B65D71/36; (IPC1-7): A61K9/16; A61K31/519; A61K38/00; A61K38/04; A61K47/32; A61K47/34

Domestic Patent References:

JPH09505308A	1997-05-27
JPH04505454A	1992-09-24
JPH11506764A	1999-06-15
JPH04506931A	1992-12-03
JPS5793912A	1982-06-11

Foreign References:

WO1989003678A1	1989-05-05
WO1999015154A1	1999-04-01

Other References:

JPN7009001185, Ｅｕｒ　ｊ　ｐｈａｒｍ　ｂｉｏｐｈａｒｍ, １９９６，　Ｖｏｌ．４２，　Ｎｏ．１, ｐａｇｅｓ　１６−２４

Attorney, Agent or Firm:

Yoshiyuki Inaba
Katsuro Tanaka
Shinji Oga

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