Title:
RESIDUAL SOLVENT EXTRACTION METHOD AND MICROPARTICLES PRODUCED THEREBY
Document Type and Number:
Japanese Patent JP2015227383
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods for preparing microparticles having reduced residual solvent levels, and microparticles prepared by the methods.SOLUTION: Microparticles are contacted with a non-aqueous washing system to reduce levels of residual solvents in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Inventors:
RICKEY MICHAEL E
RAMSTACK J MICHAEL
KUMAR RAJESH
RAMSTACK J MICHAEL
KUMAR RAJESH
Application Number:
JP2015178419A
Publication Date:
December 17, 2015
Filing Date:
September 10, 2015
Export Citation:
Assignee:
ALKERMES PHARMA IRELAND LTD
International Classes:
A61K38/22; A61K9/14; B65D5/462; A61K9/16; A61K31/519; A61K38/00; A61K38/04; A61K47/32; A61K47/34; B01J8/02; B01J13/08; B01J13/12; B01J13/20; B01J14/00; B01J19/12; B01J19/24; B65D5/46; B65D5/465; B65D71/00; B65D71/36
Domestic Patent References:
| JPS5455717A | 1979-05-04 | |||
| JPS57118512A | 1982-07-23 | |||
| JPH09505308A | 1997-05-27 | |||
| JPH07309897A | 1995-11-28 | |||
| JP2013129973A | 2013-07-04 |
Foreign References:
| WO1989003678A1 | 1989-05-05 | |||
| WO1999047588A1 | 1999-09-23 | |||
| WO1999015154A1 | 1999-04-01 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Toshifumi Onuki
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