Title:
Resolvin : The bio-template for curative treatment
Document Type and Number:
Japanese Patent JP6097536
Kind Code:
B2
Abstract:
The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.
Inventors:
Charles N. Sirhan
Application Number:
JP2012261696A
Publication Date:
March 15, 2017
Filing Date:
November 29, 2012
Export Citation:
Assignee:
The Brigham And Women's Hospital Incorporated
International Classes:
A61K31/557; C07C59/42; A61K31/19; A61K31/232; A61P29/00; C07C59/48; C07C59/54; C07C69/732; C07F7/18
Other References:
J.Exp.Med.,(2002),Vol.196,No.8,p.1025-1037
J.Biological Chemistry,(2003),Vol.278,No.17,p.14677-14687
J.Biological Chemistry,(2003),Vol.278,No.17,p.14677-14687
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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