To obtain a retinal disease-treating preparation which can inhibit the death of retinal cells, of which apoptosis and free radical are causative.
This treating preparation contains, as an active ingredient, a compound of formula I [X is phenyl, formula II ((n) is 1-5; R is H, a lower alkyl); Y1 is t-butyl], and typically, '-phenly-t-butyl-nitron is exemplified. It is effective for pigmentary degeneration of the retina, diabetic retinopathy, degeneration maculae luteae senilis, retinal separation, ophthalmological clinical examination and retinopathy caused by light accompanied by operation. It can be orally or parenterally administered and the daily dose is 1-50mg/adult in the oral case, while 0.1-100mg/day in portions once to several times is the case of intraveneous injection.
TATSUNO TORU
ITO AKIRA
