RETROVIRAL AND LENTIVIRAL VECTORS

Title:

RETROVIRAL AND LENTIVIRAL VECTORS

Document Type and Number:

Japanese Patent JP2023060000

Kind Code:

A

Abstract:

To provide retroviral and lentiviral vectors.SOLUTION: The present invention provides a retroviral vector or a lentiviral vector having a viral envelope which comprises: (i) a mitogenic T-cell activating transmembrane protein which comprises a mitogenic domain and a transmembrane domain; and/or (ii) a cytokine-based T-cell activating transmembrane protein which comprises a cytokine domain and a transmembrane domain, where the mitogenic or cytokine-based T-cell activating transmembrane protein is not part of a viral envelope glycoprotein. When cells such as T-cells of natural killer cells are transduced by such a viral vector, they are simultaneously activated by the mitogenic T-cell activating transmembrane protein and/or the cytokine-based T-cell activating transmembrane protein.SELECTED DRAWING: None

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Inventors:

Martin Pule
Layla Meccaoui

Application Number:

JP2023029559A

Publication Date:

April 27, 2023

Filing Date:

February 28, 2023

Export Citation:

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Assignee:

Otras Limited

International Classes:

C12N15/867; A61K35/76; A61K38/20; A61K39/395; C07K14/54; C07K16/28; C07K19/00; C12N5/10; C12N7/01; C12N15/12

Attorney, Agent or Firm:

Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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