Title:
Rhoキナーゼ阻害剤
Document Type and Number:
Japanese Patent JP2004524350
Kind Code:
A
Abstract:
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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Inventors:
Nagalas Nam, Danaparan
Asgari, Daboud
Xiao, Jin Shin
Riu, Xiao-gao
Keele, Udai
One, chungguan
Heart, barely
Boyer, Stephen
Weber, Olaf
Lynch mark
Bankston, Donald
Asgari, Daboud
Xiao, Jin Shin
Riu, Xiao-gao
Keele, Udai
One, chungguan
Heart, barely
Boyer, Stephen
Weber, Olaf
Lynch mark
Bankston, Donald
Application Number:
JP2002576234A
Publication Date:
August 12, 2004
Filing Date:
March 22, 2002
Export Citation:
Assignee:
Bayer corporation
International Classes:
A61K31/517; A61K31/5377; A61P1/00; A61P7/04; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/08; A61P15/00; A61P15/10; A61P19/10; A61P25/00; A61P27/06; A61P35/00; A61P43/00; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D405/14; C07D409/14; C07D413/14; (IPC1-7): C07D403/12; A61K31/517; A61K31/5377; A61P1/00; A61P7/04; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/08; A61P15/00; A61P19/10; A61P25/00; A61P27/06; A61P35/00; A61P43/00; C07D403/14; C07D405/14; C07D409/14; C07D413/14
Domestic Patent References:
| JP2000514806A | 2000-11-07 | |||
| JPH11508906A | 1999-08-03 | |||
| JP2000309577A | 2000-11-07 | |||
| JPH06336481A | 1994-12-06 |
Foreign References:
| WO1996039145A1 | 1996-12-12 | |||
| WO1995015758A1 | 1995-06-15 | |||
| GB2345486A | 2000-07-12 | |||
| WO2000044728A1 | 2000-08-03 | |||
| WO2000047212A1 | 2000-08-17 | |||
| WO1999035146A1 | 1999-07-15 | |||
| WO1999035132A1 | 1999-07-15 | |||
| WO1999006396A1 | 1999-02-11 | |||
| WO2003040109A2 | 2003-05-15 | |||
| WO2003040108A1 | 2003-05-15 |
Attorney, Agent or Firm:
Akaoka Michio
Kazuo Akaoka
Kazuo Akaoka