Title:
ROONNPUURAN SANTO
Document Type and Number:
Japanese Patent JPS5849380
Kind Code:
A
Abstract:
salts of formula are(I) are new. (where X(-) is an anion; R is 1-7C opt. branched alkyla (opt. substd. by hydroxy, carboxy, alkoxycarbonyl, cyano, dialkylamnino, alkylcarbonyl, benzoyl (where the peny phenyl ring is otpt. substd. by one or more halo, alkyl )(opt. halo substd.) alkoxy, hydroxy, amino, mono- or dialkylamino, cyano or nitro gps.) thenoyl (the thienyl ring is opt. substd. by one or more halo, alkyl, cyano, or nitro gps)., pyridylcarbonyl, carbamoyl, dialkylcarbamoyl (where the two alkyl gps. together with the N atom may form a 5-6 membered heterocyclic opt. contg. a further O, S or N (substd. by alkyl or alkylcarbonyl) atom) or pyridyl) or R is dialkylcarbamoyl (where the two alkyl gps. together with the N atom may form a 5 or 6 membered heterocyclic opt. contg. a further O, S or N (substd. by alkyl or alkylcarbonyl) heteroatom), 2-4C alkenyl, 2-4C alkynyl, alkoxycarbonyl, 2-oxo-3-tetrahydrofuryl or 2-oxo-3-tetrahydropyranyl. R1 and R2 independently are phenyl, 3-7C cycloalkyl, alkyl or phenylalkylpephenalkyl or together with the N atom form a 5-7 membered heterocyclic, opt. contg. a further O, S or alkyl-substd.-N heteroatom ot R1 is phenyl (opt. substd. by one or more halo, alkyl (opt. substd. by one or more halo gps), alkoxy, hydroxy, amino, mono- or dialkylamino, cyano or nitro), 3-7C cycloalkyl, alkyl or phenalkyl and R2 is H including the corresponding bases when R2 is H). Anti-ulcer cyto-protecting cpds. In tests against ethanol induced ulcers is rats (A Roberts technique), (I) are orally active at doses of 1-100 mg/kg.
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Inventors:
KUROODO KOTORERU
DANIERU FUARUJIYU
JIERAARU TOORAN
DANIERU FUARUJIYU
JIERAARU TOORAN
Application Number:
JP13907882A
Publication Date:
March 23, 1983
Filing Date:
August 10, 1982
Export Citation:
Assignee:
RHONE POULENC SANTE
International Classes:
A61K31/385; A61P1/04; C07C233/07; C07D295/185; C07D339/04; C07D409/12; (IPC1-7): A61K31/385; C07D213/00; C07D307/00; C07D333/00; C07D339/00; C07D339/04; C07D409/12
Attorney, Agent or Firm:
Heiyoshi Odashima