Title:
【発明の名称】エステロゲンとプロゲスタゲンステロイドホルモン受容体の特異性リガンド、その応用と合成中間生成物
Document Type and Number:
Japanese Patent JP2779011
Kind Code:
B2
Abstract:
The present invention relates to specific ligands for estrogen or progestagen steroid hormone receptors which have the formula (I) in which X denotes a vinyl group substituted by a radioactive or nonradioactive halogen on the double bond according to a Z isomerism, and Y denotes either a hydroxyl group, in which case the ring to which it is attached is an aromatic ring, or a ketone functional group, in which case it is conjugated with a double bond at C4-C5. An application of the ligands according to the invention is the targeted therapy and/or medical imagery, especially of cancer. However, these ligands can also be employed in the quantitative determination of said hormone receptors. However, the labeled ligands according to the invention are of very particular interest in the case of the targeted radiotherapy of cancer.
Inventors:
MARUKU TSUAIHIERU
JAAKU KIBI
JAAKU KIBI
Application Number:
JP27273889A
Publication Date:
July 23, 1998
Filing Date:
October 19, 1989
Export Citation:
Assignee:
RA REJON WARON
International Classes:
A61K31/565; A61K31/57; A61K49/04; A61K51/00; A61P35/00; A61P43/00; G01N33/60; C07B59/00; C07J1/00; C07J7/00; C07J17/00; C07J21/00; C07J51/00; G01N33/74; (IPC1-7): C07J7/00; A61K31/57; A61K49/04; A61K51/00; G01N33/60; G01N33/74
Attorney, Agent or Firm:
Kazuo Sato (2 outside)