ＳＣＮ９Ａアンチセンス鎮痛剤

Title:

ＳＣＮ９Ａアンチセンス鎮痛剤

Document Type and Number:

Japanese Patent JP7241019

Kind Code:

B2

Abstract:

The current invention provides peptide nucleic acid derivatives targeting the 3′ splice site of exon 4 in the human SCN9A pre-mRNA. The peptide nucleic acid derivatives potently induce SCN9A mRNA splice variant(s) lacking the SCN9A exon 4 in cells, and are useful to safely treat pains or conditions involving Nav1.7 activity.

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Inventors:

Chun, Shin
Jun, Durham
Cho, Bonjung
Jean, Kang Won
John, Hyun Joo
Bae, Jin Yun
Bae, Taeyeon
John, Eessel
Lee, Jun Young
Park, Seung Hwa
Ann, Dambi

Application Number:

JP2019539749A

Publication Date:

March 16, 2023

Filing Date:

January 23, 2018

Export Citation:

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Assignee:

Olipus Corporation

International Classes:

C12N15/113; A61K31/7125; A61P29/00; A61P43/00

Domestic Patent References:

JP2011518770A

Foreign References:

KR1020110087436A
WO2009033027A2
WO2009143277A2

Attorney, Agent or Firm:

Patent Attorney Corporation Hiraki International Patent Office

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