Title:
ＳＨＩＰ１モジュレーターおよびそれに関連する組成物および方法
Document Type and Number:
Japanese Patent JP6407951
Kind Code:
B2
Abstract:
R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
Inventors:
Mackenzie, Lloyd F.
McClurey, Thomas Bee.
Harwig, Curtis
Bogucky, david
Raymond, Jeffrey Earl.
Pettigrew, Jeremy Dee.
McClurey, Thomas Bee.
Harwig, Curtis
Bogucky, david
Raymond, Jeffrey Earl.
Pettigrew, Jeremy Dee.
Application Number:
JP2016500472A
Publication Date:
October 17, 2018
Filing Date:
February 27, 2014
Export Citation:
Assignee:
Aquinox Pharmaceuticals (Canada) Inc.
International Classes:
C07C35/21; A61K31/341; A61K31/35; A61K31/381; A61K31/416; A61K31/423; A61K31/426; A61K31/428; A61K31/435; A61K31/4406; A61K31/451; A61K31/455; A61P29/00; A61P35/00; A61P37/06; C07C35/32; C07C215/42; C07C233/23; C07C271/16; C07C275/22; C07C279/28; C07C335/10; C07D211/58; C07D213/75; C07D213/82; C07D215/227; C07D221/06; C07D231/56; C07D261/20; C07D277/24; C07D277/28; C07D277/64; C07D307/52; C07D333/16; C07D333/20; C07D493/10
Domestic Patent References:
| JP2006523624A |
Other References:
British Journal of Pharmacology,2013年 2月25日,168(6),1506-1518
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita