ＳＨＩＰ１モジュレーターおよびそれに関連する組成物および方法

Title:

ＳＨＩＰ１モジュレーターおよびそれに関連する組成物および方法

Document Type and Number:

Japanese Patent JP6407950

Kind Code:

B2

Abstract:

where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

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Inventors:

Mackenzie, Lloyd F.
Harwig, Curtis
Bogucky, david
Raymond, Jeffrey Earl.
Pettigrew, Jeremy Dee.

Application Number:

JP2016500471A

Publication Date:

October 17, 2018

Filing Date:

February 27, 2014

Export Citation:

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Assignee:

Aquinox Pharmaceuticals (Canada) Inc.

International Classes:

A61K31/047; C07C279/08; A61K31/13; A61K31/137; A61K31/155; A61K31/166; A61K31/17; A61K31/18; A61K31/19; A61K31/275; A61K31/341; A61K31/36; A61K31/40; A61K31/415; A61K31/4164; A61K31/4184; A61K31/4196; A61K31/4402; A61K31/4409; A61K31/455; A61K31/495; A61K31/4965; A61K31/505; A61K31/52; A61K31/5375; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07C35/21; C07C35/27; C07C43/164; C07C43/205; C07C59/11; C07C62/32; C07C215/42; C07C217/58; C07C217/60; C07C225/16; C07C233/21; C07C233/60; C07C233/72; C07C235/30; C07C235/48; C07C239/12; C07C255/31; C07C275/22; C07C275/24; C07C275/28; C07C311/04; C07C335/10; C07D207/333; C07D207/335; C07D213/30; C07D213/64; C07D213/82; C07D231/12; C07D233/60; C07D235/04; C07D239/34; C07D241/18; C07D249/08; C07D295/088; C07D307/68; C07D317/58; C07D473/34

Domestic Patent References:

JP2006523624A

Other References:

British Journal of Pharmacology,2013年 2月25日,168(6),1506-1518

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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