Salt of aza-2 ring type Di - A reel ether and a manufacturing method for the same, or a manufacturing method of the precursor

Japanese Patent JP6263469

B2

The present invention relates to a process for the production of a compound of formula I ((R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane) or a salt thereof and to a process for the production of a compound of formula II (5-chloro-2-(4-methylphenyl)pyridine ) or a salt thereof, which is used as an intermediate in the preparation of the compound of formula I.

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Martin, Wolfgang
Prashad, Mahavir
Wilhouer, Edwin, Bernard
Waikole, Rila Dahl, Marri Dahl
Vivero, James Anthony
Sutter, Bertrand
Bianchi, Jean-Claude
Ve, Laean
Har, dennis
Karpinsky, Peter H.
Pignon, Massimo
Stingerin, Doris
Burger, Eckert

JP2014519458A

January 17, 2018

January 13, 2012

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Novartis Age

C07D453/02; A61K9/20; A61K31/444; A61K47/02; A61K47/14; A61K47/20; A61K47/26; A61K47/36; A61K47/38; A61K47/44; A61P25/00; A61P25/18; A61P25/28; A61P43/00; C07D213/61

JP2005539057A
JP2016185963A

WO2011009890A2

C.G.WERMUTH編,「最新 創薬化学 下巻」,株式会社 テクノミック,平成11年9月25日発行,347~365頁
平山令明編著,「有機化合物結晶作成ハンドブック -原理とノウハウ-」,丸善株式会社,平成20年7月25日発行,第78,79頁
日本医薬品添加剤協会訳編,「改訂 医薬品添加物ハンドブック」,株式会社薬事日報社,2007年2月28日第1刷発行,第1079-1102頁,特に1085,1086,1091頁
International Journal of Pharmaceutics,(1986),vol.33,pp.201-217

Hiroshi Kobayashi
Norio Omori
Saori Oga
Hakoda Mitsuru
Yasuhito Suzuki

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