Title:
1-ベンジル-3-アミノピロリジンの光学純度向上方法及びそれに用いられる塩
Document Type and Number:
Japanese Patent JP4481659
Kind Code:
B2
Abstract:
Method of increasing the purity of low optical purity 1-benzyl-3-aminopyrrolidine (I) comprises converting (I) into a 1:1 mole ratio salt with an optically inactive acid and separating the salt in crystalline form. Method of increasing the purity of low optical purity 1-benzyl-3-aminopyrrolidine (I) comprises converting (I) into a 1:1 mole ratio salt with an optically inactive acid and separating the salt in crystalline form. An independent claim is also included for salts of 1-benzyl-3-aminopyrrolidine of formula (IA). [Image] HX : hydrobromic acid, methanesulfonic acid or acetic acid.
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Inventors:
Fumihiko Kano
Mori Natsuki
Mori Natsuki
Application Number:
JP2003580283A
Publication Date:
June 16, 2010
Filing Date:
March 28, 2003
Export Citation:
Assignee:
Kaneka Corporation
International Classes:
C07D207/50; C07B57/00; C07D207/14
Other References:
Ludovic Jean et al,A convenient route to 1-benzyl 3-aminopyrrolidine and 3-aminopiperidine,Tetrahedron Letters,2001年,Vol.42, Issue 33,p.5645-5649
社団法人 日本化学会,化学便覧 応用化学編,丸善株式会社,1995年,第5版,p.II-317~II-322
白岩正 他,Racemic structures and optical resolutions by preferential crystallization of (±)-1-amino-2-propanol salts of organic acids. ,日本化学会誌,1985年,No.8,p.1549-1555
社団法人 日本化学会,化学便覧 応用化学編,丸善株式会社,1995年,第5版,p.II-317~II-322
白岩正 他,Racemic structures and optical resolutions by preferential crystallization of (±)-1-amino-2-propanol salts of organic acids. ,日本化学会誌,1985年,No.8,p.1549-1555
Attorney, Agent or Firm:
Atomi International Patent Office
Yasuo Yasutomi
Yasuo Yasutomi