Title:
トリメブチン及びN-脱メチル化トリメブチンの塩類
Document Type and Number:
Japanese Patent JP5421098
Kind Code:
B2
Abstract:
Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are particularly useful in the treatment of conditions characterized by abdominal pain, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), diabetic gastroparesis, and dyspepsia.
Inventors:
Wallace, John, Elle.
Sirino, Giuzeppe
Santagada, Vinsenzo
Cariendo, Giuzeppe
Sirino, Giuzeppe
Santagada, Vinsenzo
Cariendo, Giuzeppe
Application Number:
JP2009513524A
Publication Date:
February 19, 2014
Filing Date:
June 06, 2007
Export Citation:
Assignee:
GI Care Pharma Inc.
International Classes:
C07C219/14; A61K31/192; A61K31/198; A61K31/235; A61K31/27; A61K31/385; A61K45/00; A61P1/00; A61P1/04; A61P29/00; A61P43/00; C07C279/36; C07C323/60; C07C327/48; C07D339/04
Foreign References:
| WO1998048826A1 | ||||
| WO2004006902A1 |
Other References:
European Journal of Biochemistry,Vol.172, No.3,p.761-766 (1988).
Bulletin of the Chemical Society of Japan,Vol.52, No.5,p.1431-1436 (1979).
日本化学雑誌,Vol.81, No.4,p.618-620 (1960).
The Journal of Pharmacology and Experimental Therapeutics,Vol.316, No.1,p.325-335 (2006).
Bulletin of the Chemical Society of Japan,Vol.52, No.5,p.1431-1436 (1979).
日本化学雑誌,Vol.81, No.4,p.618-620 (1960).
The Journal of Pharmacology and Experimental Therapeutics,Vol.316, No.1,p.325-335 (2006).
Attorney, Agent or Firm:
Taro Yaguchi
Junichiro Yanagi
Junichiro Yanagi