Title:
縮合環ピリミジン系化合物の塩、結晶形並びにその製造方法と使用
Document Type and Number:
Japanese Patent JP7351061
Kind Code:
B2
Abstract:
Disclosed are a salt of a fused ring pyrimidine compound, a crystal form thereof and a preparation method therefor and the use thereof. The fused ring pyrimidine compound is N-[7-(4-fluoro-2-methoxyphenyl)-6-methylthieno[3,2-d]pyrimidin-2-yl]-1-(piperidin-4-yl)-1H-pyrazol-4-amine, having a structure as shown in formula 1. The preparation methods in the invention for the salt of the fused ring pyrimidine compound and the crystal form thereof are simple; and the salt of the fused ring pyrimidine compound and the crystal form thereof at least have the characteristics of having a better stability, not easily absorbing moisture, being of a polycrystalline type, having a chemical stability and pharmacokinetics, and having an improved solubility.
Inventors:
One, Yukoan
Chan, non
Chan, Pinchin
Chan, non
Chan, Pinchin
Application Number:
JP2020566753A
Publication Date:
September 27, 2023
Filing Date:
May 10, 2019
Export Citation:
Assignee:
Guanjo Maxinobel Pharmaceuticals Company Limited
International Classes:
C07D495/04; A61K31/519; A61P35/00; A61P35/02; A61P43/00
Foreign References:
| WO2017012559A1 | ||||
| CN106279201A |
Other References:
最新 創薬化学 下巻,株式会社 テクノミック,1999年,pp.347-365
芦澤一英,医薬品の多形現象と晶析の科学,2002年,pp.273,278,305-17
芦澤一英,医薬品の多形現象と晶析の科学,2002年,pp.273,278,305-17
Attorney, Agent or Firm:
Kazunobu Kato
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