Title:
サルササポゲニン構造に基づく誘導体、医薬組成物及びその使用
Document Type and Number:
Japanese Patent JP7245918
Kind Code:
B2
Abstract:
The present invention relates to a derivative of sarsasapogenin having a structure of formula I,The present invention also provides a pharmaceutical composition of the aforementioned derivative of sarsasapogenin and use thereof. By systematic modification and derivatization of sarsasapogenin structure in combination with inhibitory activity assays on tumor cells, the inventor surprisingly found that many derivative compounds have excellent inhibitory activity on tumor cells, particularly high inhibitory activity on the growth of various brain tumor cells, having potential wide application and tremendous value in treating various cancers, making up for the deficiency of modified derivatives of sarsasapogenin in the prior art and having important scientific and commercial application value.
Inventors:
Mu, Sean
One, ner
One, ner
Application Number:
JP2021542240A
Publication Date:
March 24, 2023
Filing Date:
May 13, 2019
Export Citation:
Assignee:
PHYTOVENT BIOPHARMA
International Classes:
C07J71/00; A61K31/58; A61K39/395; A61K45/00; A61P25/00; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P43/00
Foreign References:
| WO2018121770A1 | ||||
| CN106977581A |
Attorney, Agent or Firm:
Patent Attorney Corporation Maku Patent Office