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Title:
SATURATED HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVE
Document Type and Number:
Japanese Patent JP02000179
Kind Code:
A
Abstract:

NEW MATERIAL:The compound of formula I [R1 is 5-6-membered heterocyclic group which may be condensed with benzene ring; R2 is H, alkyl or R1; X1 is O, S or CH2; Y1 is O, S or NR4 (R4 is H, alkyl or carboxy); A1 is methylene or ethylene; R3 is NR5R6, group of formula II, formula III (one of R5 and R6 is H or hydrocarbon group and the other is hydrocarbon group or R1; A2 and A3 are alkylene; Z is CH or N; R7 is H, hydrocarbon group, carboxy, acyl, carbamoyl, etc.), etc.] or its salt.

EXAMPLE: [N-tert-butoxycarbonyl-2-(3-pyridyl) thiazolidine-4-carbo-nyl]-L-methio- nine methyl ester.

USE: A drug composition having antagonistic action against platelet activating factor.

PREPARATION: The compound of formula I can be produced by reacting a compound of formula IV [R12, R13 and Y2 are (protected) R1, R2 and Y1) with a compound of formula H-R14 [R14 is (protected) R3] and, as necessary, removing the protecting group.


Inventors:
Mase, Toshiyasu
Hara, Hiroshi
Nagaoka, Hitoshi
Suzuki, Takeshi
Takahashi, Takumi
Tomioka, Kenichi
Yamada, Toshimitsu
Application Number:
JP1988000037224
Publication Date:
January 05, 1990
Filing Date:
February 19, 1988
Export Citation:
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Assignee:
YAMANOUCHI PHARMACEUT CO LTD
International Classes:
C07D209/48; A61K31/44; A61K31/4427; A61K31/443; A61K31/495; A61P7/02; C07D211/12; C07D211/16; C07D211/22; C07D211/30; C07D211/32; C07D211/62; C07D243/08; C07D295/02; C07D295/06; C07D295/08; C07D295/10; C07D295/18; C07D295/20; C07D401/04; C07D405/04; C07D413/04; C07D417/04; C07D417/14; C07D513/04; (IPC1-7): A61K31/44; A61K31/495; C07D209/48; C07D211/12; C07D211/32; C07D243/08; C07D295/02; C07D295/06; C07D295/08; C07D295/10; C07D295/18; C07D295/20; C07D401/04; C07D405/04; C07D413/04; C07D417/04; C07D417/14; C07D513/04