Title:
ＵＳＰ４阻害剤を用いたスクリーニングおよび処置の方法
Document Type and Number:
Japanese Patent JP6882199
Kind Code:
B2
Abstract:
The present application relates to materials and methods for exploiting synthetic lethality and/or chemo-sensitisation in DNA damage response (DDR) pathways. In particular, the application relates to ubiquitin hydrolase protein Ubiquitin Specific Protease 4 (USP4) and its association with DDR pathways. Further, the use of USP4 inhibitors in the treatment of cancer and methods of screening is described, in particular, use of inhibitors of USP4 in the treatment of tumours defective in double-strand break repair (DSBR) and/or tumours resistant to platinum-based chemotherapy, or to sensitise, i.e. chemosensitise or radiosensitise tumours to other therapeutic agents.
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Inventors:
Xavier jack
Helen Robinson
Yaara Ophir-Rosenfeld
Stephen Jackson
Paul Weinhofen
Ryotaro Nishi
Helen Robinson
Yaara Ophir-Rosenfeld
Stephen Jackson
Paul Weinhofen
Ryotaro Nishi
Application Number:
JP2017563390A
Publication Date:
June 02, 2021
Filing Date:
February 29, 2016
Export Citation:
Assignee:
Mission Therapeutics Limited
International Classes:
A61K31/7105; A61K31/282; A61K31/4745; A61K31/502; A61K31/7048; A61K45/00; A61K48/00; A61P35/00; A61P35/02; A61P43/00; C07K2/00; C07K16/40; C12N9/99; C12N15/00; C12N15/113; C12N15/115; C12Q1/04; C12Q1/68; G01N33/15; G01N33/48; G01N33/50; G01N33/68
Other References:
Bioorganic & Medicinal Chemistry Letters,2013年,Vol.23,Issue 15,Pages 4328-4331
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Takahide Sasaki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Takahide Sasaki
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