Title:
線維症の治療において使用する化合物の同定のためのCTGF及びTRKAレセプターを使用するスクリーニング方法
Document Type and Number:
Japanese Patent JP2007515162
Kind Code:
A
Abstract:
The invention provides a method for identifying and/or making compounds for use in reducing and/or preventing fibrosis, comprising the steps: providing a CTGF receptor; providing a test sample; providing a CTGF receptor agonist; exposing the CTGF receptor to the test sample; subsequently or simultaneously exposing the CTGF receptor to the CTGF receptor agonist; detecting and/or measuring the amount of CTGF receptor activation; comparing the amount of CTGF receptor activation detected and/or measured in the presence of the test sample with the amount of CTGF receptor activation detected and/or measured in the absence of a test sample; determining if a compound reduces and/or prevents fibrosis on the basis that it causes no increase or a decrease in CTGF receptor activation. There is also provided compounds for reducing and/or preventing fibrosis and uses of such compounds.
Inventors:
Roger Maxwell Mason
Nadia Abdul Wahab
Nadia Abdul Wahab
Application Number:
JP2006540577A
Publication Date:
June 14, 2007
Filing Date:
November 15, 2004
Export Citation:
Assignee:
Imperial Innovations Limited
International Classes:
C12N15/09; A61K31/7088; A61K38/00; A61K39/00; A61K39/395; A61K45/00; A61K48/00; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P21/00; A61P27/02; A61P35/00; A61P43/00; C07K14/705; C07K16/00; C07K16/46; C12N5/10; G01N33/15; G01N33/50; G01N33/74
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro