Ｇタンパク質共役受容体および関連組成物を使用するスクリーニング方法

Japanese Patent JP5711966

B2

The present invention relates to a polypeptide, or pharmaceutically acceptable salt thereof, comprising the formula PTH(1-X)/PTHrP(Y-36). Further, the present invention refers to a polypeptide which binds the PTH receptor and has a high affinity for the R 0 form of the PTH receptor and to a polypeptide having affinity for PTH RG and a low affinity for PTH R 0 . Moreover, the present invention includes to a pharmaceutical composition comprising such polypeptide. The present invention further relates to a polypeptide or a pharmaceutical composition of the present invention for use in a method for treating a disease or condition. Moreover, the present invention refers to a nucleic acid comprising a sequence encoding a polypeptide of the present invention, a vector comprising said nucleic acid, a cell comprising said vector and a method of making a polypeptide of the present invention. Finally, the present invention further relates to a method for determining whether a candidate compound is a long-acting agonist of a G protein coupled receptor (GPCR).

Gardener Thomas Jay.
Potts John Tea.
Masaru Shimizu
Fumihiko Ichikawa
Jupner Harald Tea.
Makoto Okazaki

JP2010519932A

May 07, 2015

August 01, 2008

Click for automatic bibliography generation  

The General Hospital Corporation
Chugai Pharmaceutical Co., Ltd.

C12Q1/02; A61K38/00; A61P5/18; A61P19/08; A61P19/10; A61P43/00; C07K14/635; C12N15/09; C40B30/06; G01N33/15; G01N33/50

The Journal of Clinical Endocrinology & Metabolism,2003年,Vol.88,p.569-575
Journal of Bone and Mineral Research,2006年,Vol.21,p.354-365
The Journal of Biological Chemistry,2001年,Vol.276,p.7741-7753

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto

Previous Patent: 恒温装置

Next Patent: JPS5711967