To provide a non-antigenic and harmless cell sheet, having selective permeability, capable of retaining the activity of secretory cells for long time and capable of accurately regulating the shape and size, etc. of the secretory cells; and a method of manufacturing the same.

A biocompatible hydrophobic (meth) acrylate copolymer, a photopolymerizable compound and a photopolymerizable composition including a photopolymerization initiator are photopolymerized to make the cell sheet, and a liquid phase including secretory cells inside is embedded in the cell sheet.