SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME

Japanese Patent JP2023116627

A

To provide compounds, pharmaceutical compositions and methods of use that are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes, and useful in treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory diseases, autoimmune diseases and cancers.SOLUTION: The present disclosure relates to a compounds of formula (I) in the figure, or a prodrug, hydrate, solvate or pharmaceutically acceptable salt thereof. In the formula, R1 is cycloalkyl, aryl, heterocycloalkyl, or heteroaryl; R3 is H or alkyl; R4 is H, alkyl, -(CH2)0-3-cycloalkyl, or -(CH2)0-3-aryl; and R6 is alkyl, alkenyl, alkoxy, cycloalkyl, halo, oxo, -OH, -CN, -NH2, -CH2F, -CHF2, -CF3, or the like.SELECTED DRAWING: None

MARK G BOCK
ALAN PAUL WATT
RODERICK ALAN PORTER
DAVID HARRISON
NICOLAS FELIX PIERRE BOUTARD
OLEKSANDR LEVENETS
CHARLES-HENRY ROBERT YVES FABRITIUS
GRZEGORZ WITOLD TOPOLNICKI

JP2023094466A

August 22, 2023

June 08, 2023

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NODTHERA LTD

C07C271/30; A61K31/27; A61K31/343; A61K31/351; A61K31/415; A61K31/4164; A61K31/4196; A61K31/4402; A61K31/4406; A61K31/4965; A61K31/497; A61K31/50; A61K31/505; A61P1/04; A61P1/16; A61P3/04; A61P3/10; A61P11/00; A61P13/12; A61P17/00; A61P19/02; A61P19/06; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P35/04; A61P37/02; A61P43/00; C07C271/28; C07D213/55; C07D231/12; C07D231/14; C07D231/16; C07D231/18; C07D233/54; C07D237/08; C07D239/26; C07D241/12; C07D249/08; C07D307/82; C07D309/12; C07D409/12; C07D493/04

Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto

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