Title:
糖尿病を治療するための選択的アンドロゲン受容体モジュレータ
Document Type and Number:
Japanese Patent JP2010523683
Kind Code:
A
Abstract:
A composition comprising a compound of formula III characterized by the structure:
or its isomer, pharmaceutically acceptable salt, pharmaceutical product, hydrate, or N -oxide, and a chemotherapeutic agent. The chemotherapeutic agent may comprise a taxane and a platinum compound, such as carboplatin and docetaxel. The composition is for use in treating cancer in a subject.
Inventors:
Dalton, James Tee
Miller, Duane Dee
Miller, Duane Dee
Application Number:
JP2010503088A
Publication Date:
July 15, 2010
Filing Date:
April 14, 2008
Export Citation:
Assignee:
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
International Classes:
A61K31/277; A61K45/00; A61P1/16; A61P3/04; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P13/00; A61P13/12; A61P19/00; A61P27/02; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2006505563A | 2006-02-16 | |||
| JP2006505563A | 2006-02-16 | |||
| JP2007505118A | 2007-03-08 |
Foreign References:
| US20040087557A1 | 2004-05-06 | |||
| US20040087557A1 | 2004-05-06 | |||
| WO2005120483A2 | 2005-12-22 | |||
| US20060229362A1 | 2006-10-12 |
Other References:
JPN6013015847; Ｋｉｍ Ｊ ｅｔ ａｌ．: 'Ｔｈｅ ｐａｒａ ｓｕｂｓｔｉｔｕｅｎｔ ｏｆ Ｓ-３-（ｐｈｅｎｏｘｙ）-２-ｈｙｄｒｏｘｙ-２-ｍｅｔｈｙｌ-Ｎ-（４-ｎｉｔｒｏ-３-ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌ-ｐｈｅｎｙｌ）-ｐｒｏｐｉｏ' Ｊ Ｐｈａｒｍａｃｏｌ Ｅｘｐ Ｔｈｅｒ． Ｖｏｌ．３１５ Ｎｏ．１, 20050629, ｐｐ．２３０-２３９
JPN6013015847; Ｋｉｍ Ｊ ｅｔ ａｌ．: 'Ｔｈｅ ｐａｒａ ｓｕｂｓｔｉｔｕｅｎｔ ｏｆ Ｓ-３-（ｐｈｅｎｏｘｙ）-２-ｈｙｄｒｏｘｙ-２-ｍｅｔｈｙｌ-Ｎ-（４-ｎｉｔｒｏ-３-ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌ-ｐｈｅｎｙｌ）-ｐｒｏｐｉｏ' Ｊ Ｐｈａｒｍａｃｏｌ Ｅｘｐ Ｔｈｅｒ． Ｖｏｌ．３１５ Ｎｏ．１, 20050629, ｐｐ．２３０-２３９
JPN6013051008; Ｆｕｋｕｉ Ｍ ｅｔ ａｌ．: 'Ｒｏｌｅ ｏｆ ｅｎｄｏｇｅｎｏｕｓ ａｎｄｒｏｇｅｎ ａｇａｉｎｓｔ ｉｎｓｕｌｉｎ ｒｅｓｉｓｔａｎｃｅ ａｎｄ ａｔｈｅｒｏ- ｓｃｌｅｒｏｓｉｓ ｉｎ ｍｅｎ ｗｉｔｈ ｔｙｐｅ ２ ｄｉａｂ' Ｃｕｒｒ Ｄｉａｂｅｔｅｓ Ｒｅｖ． Ｖｏｌ．３ Ｎｏ．１, 200702, ｐｐ．２５-３１
JPN6013051011; Ｂｏｙａｎｏｖ ＭＡ ｅｔ ａｌ．: 'Ｔｅｓｔｏｓｔｅｒｏｎｅ ｓｕｐｐｌｅｍｅｎｔａｔｉｏｎ ｉｎ ｍｅｎ ｗｉｔｈ ｔｙｐｅ ２ ｄｉａｂｅｔｅｓ， ｖｉｓｃｅｒａｌ ｏｂｅｓｉｔｙ ａｎｄ ｐａｒｔｉａｌ ａｎｄｒｏｇｅｎ ｄｅｆｉ' Ａｇｉｎｇ Ｍａｌｅ． Ｖｏｌ．６ Ｎｏ．１, 200303, ｐｐ．１-７
JPN6013015847; Ｋｉｍ Ｊ ｅｔ ａｌ．: 'Ｔｈｅ ｐａｒａ ｓｕｂｓｔｉｔｕｅｎｔ ｏｆ Ｓ-３-（ｐｈｅｎｏｘｙ）-２-ｈｙｄｒｏｘｙ-２-ｍｅｔｈｙｌ-Ｎ-（４-ｎｉｔｒｏ-３-ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌ-ｐｈｅｎｙｌ）-ｐｒｏｐｉｏ' Ｊ Ｐｈａｒｍａｃｏｌ Ｅｘｐ Ｔｈｅｒ． Ｖｏｌ．３１５ Ｎｏ．１, 20050629, ｐｐ．２３０-２３９
JPN6013051008; Ｆｕｋｕｉ Ｍ ｅｔ ａｌ．: 'Ｒｏｌｅ ｏｆ ｅｎｄｏｇｅｎｏｕｓ ａｎｄｒｏｇｅｎ ａｇａｉｎｓｔ ｉｎｓｕｌｉｎ ｒｅｓｉｓｔａｎｃｅ ａｎｄ ａｔｈｅｒｏ- ｓｃｌｅｒｏｓｉｓ ｉｎ ｍｅｎ ｗｉｔｈ ｔｙｐｅ ２ ｄｉａｂ' Ｃｕｒｒ Ｄｉａｂｅｔｅｓ Ｒｅｖ． Ｖｏｌ．３ Ｎｏ．１, 200702, ｐｐ．２５-３１
JPN6013051011; Ｂｏｙａｎｏｖ ＭＡ ｅｔ ａｌ．: 'Ｔｅｓｔｏｓｔｅｒｏｎｅ ｓｕｐｐｌｅｍｅｎｔａｔｉｏｎ ｉｎ ｍｅｎ ｗｉｔｈ ｔｙｐｅ ２ ｄｉａｂｅｔｅｓ， ｖｉｓｃｅｒａｌ ｏｂｅｓｉｔｙ ａｎｄ ｐａｒｔｉａｌ ａｎｄｒｏｇｅｎ ｄｅｆｉ' Ａｇｉｎｇ Ｍａｌｅ． Ｖｏｌ．６ Ｎｏ．１, 200303, ｐｐ．１-７
Attorney, Agent or Firm:
Yoichi Oshima