SELF-ADDRESSABLE AND SELF-ASSEMBLING MICROELECTRONIC SYSTEM AND DEVICE FOR MOLECULAR BIOLOGICAL ANALYSIS AND DIAGNOSTICS

Japanese Patent JP2007020568

A

To provide a design, fabrication and use of a self-addressable and self-assembling microelectronic system capable of positively carrying out multiple steps and multiplex reactions in microscopic formats.

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, antibody/antigen reactions, diagnostics, and biopolymer synthesis. The device can electronically control the transport and attachment of specific binding entities to addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.

HELLER MICHAEL J
TU EUGENE
EVANS GLEN A
SOSNOWSKI RONALD G

JP2006184471A

February 01, 2007

July 04, 2006

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NANOGEN INC

C12P19/34; B01J19/00; G01N21/64; B01L3/00; B82B1/00; B82B3/00; C07B61/00; C07H21/00; C07K1/04; C12N15/09; C12Q1/68; C12Q1/6813; C12Q1/6816; C12Q1/6825; C12Q1/6837; G01N27/27; G01N27/327; G01N27/333; G01N27/416; G01N27/447; G01N33/53; G01N33/566; G01N37/00; G11C13/02; G11C19/00; H01L21/336; H01L21/98; H01L29/78; H01L51/05; H01L51/30; H01L51/40; H05K1/02; C40B40/06; C40B40/10; C40B40/12; C40B60/14

Aoyama Aoi
Mitsuo Tanaka
Masaki Yano

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