Title:
親油性化合物用の自己乳化性処方
Document Type and Number:
Japanese Patent JP5227301
Kind Code:
B2
Abstract:
Pharmaceutical composition comprises active, mixture of diglyceride and monoglyceride, solvents and surfactants. - Pharmaceutical composition comprises: (a) a lipophilic active agent; (b) a mixture of diglyceride and monoglyceride in a wt. ratio of 9:1-6:4 (diglyceride:monoglyceride); (c) >= 1 solvents and (d) >= 1 surfactant. The diglyceride and monoglyceride are mono- or di-unsaturated fatty acid esters of glycerol having a chain length of 16-22C. Also included is an INDEPENDENT CLAIM for a self emulsifying formulation vehicle for lipophilic active agents which comprises (b), (c) and (d) as above.
Inventors:
Walter Morozwich
Ping Gao
Ping Gao
Application Number:
JP2009291821A
Publication Date:
July 03, 2013
Filing Date:
December 24, 2009
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
A61J3/07; A61K47/14; A61K9/107; C07D405/12; A61K9/48; A61K31/192; A61K31/337; A61K31/355; A61K31/366; A61K31/4166; A61K31/4433; A61K31/4439; A61K31/4745; A61K31/496; A61K31/5575; A61K31/568; A61K31/57; A61K47/10; A61K47/16; A61K47/18; A61K47/22; A61K47/34; A61P31/14; A61P31/18; A61P37/04
Domestic Patent References:
| JP5186365A | ||||
| JP6199683A | ||||
| JP2002510329A | ||||
| JP5211853A | ||||
| JP52094412A | ||||
| JP63132826A | ||||
| JP4217912A |
Foreign References:
| WO1995030670A1 | ||||
| WO1997012626A1 | ||||
| US3268346 |
Other References:
長塚正明, et al.,ジグリセライドの乳化剤としての性質,日本化粧品技術者会誌,1980年,Vol. 14, No. 2,p. 153-158
Matuszewska B, et al.,Comparative bioavailability of L-683,453, a 5α-reductase inhibitor, from a self-emulsifying drug delivery system in Beagle dogs,International Journal of Pharmaceutics,1996年 6月14日,Vol. 136, No. 1-2,p. 147-154
Matuszewska B, et al.,Comparative bioavailability of L-683,453, a 5α-reductase inhibitor, from a self-emulsifying drug delivery system in Beagle dogs,International Journal of Pharmaceutics,1996年 6月14日,Vol. 136, No. 1-2,p. 147-154
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tsuyoshi Sato
Hiroshi Yamazaki
Tsuyoshi Sato