Title:
SEPARATION OF ISOMER OF 3,4-DIHYDROXYPHENYLSERINE
Document Type and Number:
Japanese Patent JPH07278074
Kind Code:
A
Abstract:
PURPOSE: To provide a method for extremely effectively separating the isomer of 3,4-dihydroxyphenylserine by liquid chromatography and provide a method for easily determining the optical purity of L-threo-3,4-dihydroxyphenylserine in high accuracy by using the separation method.
CONSTITUTION: This method for separating a 3,4-dihydroxyphenylserine isomer by liquid chromatography comprises the use of an aminoalkyl-bonded silica gel chemically bonded with N-[(R)-1-(α-naphthyl)ethylaminocarbonyl]-(S)-proline as the stationary phase and a solution consisting of n-hexane/1,2'-dichloroethane/ methanol incorporated with a proper amount of trifluoroacetic acid as the mobile phase.
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Inventors:
OKAMOTO MASAHIKO
Application Number:
JP7049494A
Publication Date:
October 24, 1995
Filing Date:
April 08, 1994
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO
SUMITOMO PHARMA
SUMITOMO PHARMA
International Classes:
A41D15/04; A45F4/02; C07C227/38; C07C229/36; B01D15/08; (IPC1-7): C07C229/36; B01D15/08; C07C227/38
Attorney, Agent or Firm:
Takashi Kuboyama (1 person outside)
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