Title:
トランス-7-(ヒドロキシメチル)オクタヒドロ-2H-ピリド[1,2-a]ピラジンの分離
Document Type and Number:
Japanese Patent JP2004521876
Kind Code:
A
Abstract:
The invention provides a process for the optical resolution of a racemic mixture, or an otpionally enriched mixture, of trans-7-(hydromethyl)octa-hydro-2H-pyrido-1,2a)pyrazine, a key intermediate for preparing pharmacologically active 2,7-substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives useful in the treatment of disorders of the dopamine system. The process of the invention involves use of D-(-) or L-(+)naporxen as a resolving agent.
Inventors:
Arthur Eugene Harms
Application Number:
JP2002546547A
Publication Date:
July 22, 2004
Filing Date:
October 26, 2001
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07B57/00; C07C59/64; C07D471/04; (IPC1-7): C07D471/04; C07C59/64
Attorney, Agent or Firm:
Yoshinobu Murofushi