To provide a sewing machine for corrugated cardboard capable of highly efficiently sewing a corrugated cardboard box.

This sewing machine 10 for the corrugated cardboard is provided with a set position for setting the corrugated cardboard 70 before the sewing between a patch margin and a sewing-up portion 73 via a plate guide 22 with the patch margin 72 disposed in a position corresponding to the sewing-up portion 73 of the corrugated cardboard; a shift means 30 shifting the corrugated cardboard 70 before sewing set in the set position to a sewing-up position 25; a sewing machine needle mechanism 50 for sewing up and a looper mechanism 60; a power source; and a first timing belt 42 disposed in the space 22a inside the plate guide 22. The power is transmitted to the looper mechanism 60 by the power source via the first timing belt through the space 22a inside the plate guide 22 and the sewing machine needle mechanism 50 is directly driven by the power source.