Title:
SEX STEROID INHIBITOR
Document Type and Number:
Japanese Patent JP3273010
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a compound useful for treating a disease corresponding to a sex steroid.
SOLUTION: This sex steroid inhibitor has a molecular structure of formula I (a dotted line is a double bond; R5 and R6 are each H, hydroxyl, etc.; R100 is a divalent part separating L from B ring by 4-10 interjacent atoms; L is a divalent or trivalent polar part such as CO, SO and CON; G' is absence or H, a 1-5C hydrocarbon, a 5-7C cycloalkyl, etc.; G2 is absence or H, a 1-5C hydrocarbon, or a divalent part, etc.; forming 5 to 7-membered heterocycle by binding with the G' and L), e.g. 6-hydroxy-2-(4'-hydroxyphenyl)-1-methyl-3-(6"-piperidino) hexyl-3,4-dihydronaphthalene. The compound is obtained by carrying out an acidic hydrolysis of a compound of formula II [(n) is 6; RaRb is C5H10; Rc is CH3]. The sex steroid inhibitor has an antiestrogen activities and useful for treatment of breast cancer, uterine caner, ovarian cancer, prostatic cancer, precocious puberty, benign prostatic hyperplasia, common acne, virilism, androgen alopecia, etc.
More Like This:
| WO/2016/089990 | SULFIDE ALKYL AND PYRIDYL REVERSE SULFONAMIDE COMPOUNDS FOR HBV TREATMENT |
| JPS5728040 | PHENYLETHANOLAMINE DERIVATIVE |
| JPS5630961 | ARYLSULFOXIDE ENZYME INHIBITOR |
Inventors:
Laburi, Fernand
Melon, eve
Melon, eve
Application Number:
JP1065498A
Publication Date:
April 08, 2002
Filing Date:
January 22, 1998
Export Citation:
Assignee:
ENDORECHERCHE, INC.
International Classes:
A61K31/10; A61K31/135; A61K31/138; A61K31/165; A61K31/35; A61K31/352; A61K31/38; A61K31/382; A61K31/40; A61K31/4025; A61K31/403; A61K31/404; A61K31/435; A61K31/445; A61K31/4453; A61K31/452; A61K31/4523; A61K31/453; C07D295/08; A61K31/4535; A61K31/47; A61K31/4709; A61K31/472; A61K31/4725; A61K31/535; A61K31/5375; A61K31/565; A61K31/57; A61P5/28; A61P5/32; A61P15/16; A61P17/08; A61P17/14; A61P35/00; C07C215/64; C07C217/18; C07C235/34; C07C235/40; C07C317/10; C07C317/18; C07D209/08; C07D209/12; C07D215/06; C07D215/14; C07D215/20; C07D217/04; C07D217/16; C07D235/18; C07D295/084; C07D295/092; C07D295/096; C07D295/185; C07D311/02; C07D311/04; C07D311/60; C07D335/06; C07D335/08; C07D401/06; C07D401/12; C07D405/06; C07D405/12; C07D413/12; C07J1/00; C07J17/00; C07J21/00; C07J41/00; C07J51/00; C07J53/00; C07J71/00; (IPC1-7): C07C317/18; A61K31/10; A61K31/135; A61K31/35; A61K31/38; A61K31/40; A61K31/445; A61K31/47; A61K31/535; A61K31/565; A61K31/57; C07D209/12; C07D217/04; C07D295/08; C07D335/08; C07J41/00; C07J53/00; C07J71/00
Attorney, Agent or Firm:
Fukami Hisaro (3 outside)