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Patent Searching and Data


Title:
SHIP1モデュレーター
Document Type and Number:
Japanese Patent JP4753581
Kind Code:
B2
Abstract:
The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP I activity and methods of synthesis thereof.

Inventors:
Raymond Andersen
David E Williams
Alice Mui
Christopher On
Gerald Crystal
Le Yang
Application Number:
JP2004543854A
Publication Date:
August 24, 2011
Filing Date:
April 23, 2003
Export Citation:
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Assignee:
The University of British Columbia
International Classes:
C07J63/00; A61K31/56; A61K31/565; A61P7/00; A61P29/00; A61P35/00; A61P35/02; A61P37/00; C07J69/00
Other References:
ROSALES, V.,Regioselective Palladium-Catalyzed Alkylation of Allylic Halides with Benzylic Grignard Reagents. Two-Step Synthesis of Abietane Terpenes and Tetracyclic Polyprenoid Compounds,The Journal of Organic Chemistry,2002年,67(4),p. 1167-1170
ISHIHARA, K.,Enantio- and Diastereoselective Stepwise Cyclization of Polyprenoids Induced by Chiral and Achiral LBAs. A New Entry to (-)-Ambrox, (+)-Podocarpa-8,11,13-triene Diterpenoids, and (-)-Tetracyclic Polyprenoid of Sedimentary Origin,Journal of the American Chemical Society,2002年,124(14),p. 3647-3655
HARRING, S. R.,Polyene Cascade Cyclizations Mediated by BF3・CH3NO2. An Unusually Efficient Method for the Direct, Stereospecific Synthesis of Polycyclic Intermediates via Cationic Initiation at Non-functionalized 3° Alkenes. An Application to the Total Synthesis of (±)-Taxodione.,Tetrahedron,1994年,50(31),p. 9229-9254
BOREHAM, C. J.,Structure and origin of the two major monoaromatic hydrocarbons in a tasmanite oil shale from Tasmania, Australia,Organic Geochemistry,1995年,23(5),p. 461-466
ANSELL, M. F.,Reduced Cyclic Compounds. Part I. The Preparation and Cyclodehydration of ω-Phenyl Unsaturated Tertiary Alcohols.,Journal of the Chemical Society,1956年,p. 1238-1242
GOCLIK,EVA,JOURNAL OF NATURAL PRODUCTS,2000年,V63 N8,P1150-1152
HE W,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,1998年12月15日,V8 N24,P3659-3664
Attorney, Agent or Firm:
Kyousei Tamura
Minato Saito
Nagatoshi Shinagawa