Title:
短鎖干渉RNA(siRNA)アナログ
Document Type and Number:
Japanese Patent JP4755972
Kind Code:
B2
Abstract:
The present invention is directed to double-stranded short interfering (siRNA) analogues comprising locked nucleic acid (LNA) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). The compounds disclosed herein has improved properties compared to non-modified siRNAs and may, accordingly, be useful as therapeutic agents, e.g., in the treatment of various cancer forms. More particularly, the present invention is directed to siRNA analogues comprising a sense strand and an antisense strand, wherein each strand comprises 12-35 nucleotides and wherein the siRNA analogues comprise at least one locked nucleic acid (LNA) monomer.
Inventors:
Joachim Elmen
Crace Varlestedt
Jikai Liang
Anders Malling Serensen
Henrik Elm
Trelles Koch
Crace Varlestedt
Jikai Liang
Anders Malling Serensen
Henrik Elm
Trelles Koch
Application Number:
JP2006504331A
Publication Date:
August 24, 2011
Filing Date:
March 22, 2004
Export Citation:
Assignee:
SANTARIS PHARMA A/S
International Classes:
C07H21/02; A61K31/713; A61K45/00; A61K48/00; A61P1/04; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/08; A61P13/10; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P27/02; A61P29/00; A61P31/10; A61P31/12; A61P31/16; A61P35/00; A61P37/02; A61P37/08; C12N15/11; C12N15/113; A61K38/00; C12N15/09
Other References:
HAMADA M.,ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT,MARY ANN LIEBERT, INC,2002年10月,V12 N5,P301-309
Use Bulletin 94 Mode 38X and ABI 39X Nucleic Acis Synthesizer,2001年,http://www3.appliedbiosystems.com/cms/gr
Use Bulletin 94 Mode 38X and ABI 39X Nucleic Acis Synthesizer,2001年,http://www3.appliedbiosystems.com/cms/gr
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka