Title:
短時間作用性ベンゾジアゼピン類
Document Type and Number:
Japanese Patent JP4769759
Kind Code:
B2
Abstract:
It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.
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Inventors:
Paul, El. Feldman
David, Kendall, Jung
Istvan, Calder
Gregory, Jay Pakovsky
Jeffrey A. Stafford
Jeffrey H. Tidwell
David, Kendall, Jung
Istvan, Calder
Gregory, Jay Pakovsky
Jeffrey A. Stafford
Jeffrey H. Tidwell
Application Number:
JP2007127245A
Publication Date:
September 07, 2011
Filing Date:
May 11, 2007
Export Citation:
Assignee:
CENES LIMITED
International Classes:
C07D243/20; A61K31/5513; A61K31/5517; A61P21/02; A61P25/00; A61P25/20; A61P25/22; A61P43/00; C07D243/22; C07D243/24; C07D243/32; C07D401/04; C07D401/12; C07D403/12; C07D487/04
Other References:
Boll. Chim. Farm., 1974, Vol.113, pp.642-644
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota