Title:
JCウイルスのVP-1に対するsiRNA、及びそれを含有してなる医薬組成物
Document Type and Number:
Japanese Patent JP4672654
Kind Code:
B2
Abstract:
[PROBLEMS] To provide a medicinal composition for treating JC virus infection such as progressive multifocal leukoencephalopathy (PML) by inhibiting the expression of VP-1 and inhibiting the proliferation of JC virus, a polynucleotide therefor and utilization of the same. [MEANS FOR SOLVING PROBLEMS] It is intended to provide a medicinal composition for treating JC virus-infected cells by the RNAi method with the use of a short interfering RNA (siRNA) to a gene encoding VP-1 of JC virus and a polynucleotide which is the active ingredient therefor. Namely, a medicinal composition for treating JC virus infection comprising a short interfering RNA (siRNA) to a gene encoding VP-1 of JC virus or a gene capable of forming this siRNA and a pharmaceutically acceptable carrier; a polynucleotide therefor; and utilization for producing the same.
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Inventors:
Kazuro Nagashima
Sawa Hirofumi
Yasuko Ohba
Sawa Hirofumi
Yasuko Ohba
Application Number:
JP2006513677A
Publication Date:
April 20, 2011
Filing Date:
April 26, 2005
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
A61K48/00; A61K31/7088; A61K31/7105; A61K35/76; A61K45/00; A61P25/00; A61P31/12; A61P31/20; C12N15/09; C12N15/113
Domestic Patent References:
| JP2003160510A | 2003-06-03 |
Attorney, Agent or Firm:
Norio Saeki