Title:
SIMPLE PRODUCTION METHOD OF ASEPTIC BRINZOLAMIDE SUSPENSION FORMULATION
Document Type and Number:
Japanese Patent JP2014162733
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an aqueous composition allowing production of a quantitative aqueous composition in a standard production facility due to a less number of production steps, easily ensuring asepsis, requiring no heating sterilization of brinzolamide, comprising fine particles of brinzolamide, and being preferable as a medicine.SOLUTION: A method comprises (1) a dissolution step of dissolving brinzolamide in an acidic aqueous solution to obtain an acid solution, (2) a filtration step of aseptically filtering the acid solution to obtain filtered water, (3) a mixing step of mixing the filtered water with a carboxyvinyl polymer to give mixed water, and (4) a pH adjustment step of mixing the mixed water with a pH adjusting agent under agitation condition and modifying the pH to obtain an aqueous composing agent comprising particles of the brinzolamide, where an aqueous composition comprising particles of brinzolamide is produced by mixing the aqueous solution obtained in (3) with a pH adjusting agent under agitation condition and modifying the pH.
Inventors:
KOJIMA HISATAKE
KAJIWARA YOSHIKO
KURACHI MINA
MATSUDA SHINJI
OTA TOMOHIRO
KAJIWARA YOSHIKO
KURACHI MINA
MATSUDA SHINJI
OTA TOMOHIRO
Application Number:
JP2013032727A
Publication Date:
September 08, 2014
Filing Date:
February 22, 2013
Export Citation:
Assignee:
NIPPON TENGANYAKU KENKYUSHO KK
International Classes:
A61K31/542; A61K9/10; A61K47/02; A61K47/12; A61K47/14; A61K47/22; A61K47/32; A61K47/34; A61P27/02; A61P27/06; A61P43/00
Attorney, Agent or Firm:
Yohei Kobayashi