Title:
一本鎖ＣＤ１３７受容体アゴニストタンパク質
Document Type and Number:
Japanese Patent JP7033062
Kind Code:
B2
Abstract:
Provided herein are specific CD137 receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a CD137L-associated disease or disorder. The CD137 receptor agonist proteins provided herein comprise three soluble CD137L domains and an Fe fragment. The CD137 receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
Inventors:
Christian gifels
Oliver Hill
Mainorf Tiemann
Tim Schneider
Oliver Hill
Mainorf Tiemann
Tim Schneider
Application Number:
JP2018521279A
Publication Date:
March 09, 2022
Filing Date:
October 24, 2016
Export Citation:
Assignee:
Apogenics Age
International Classes:
C12N15/62; A01K67/027; A61K38/16; A61K47/68; A61K48/00; A61P3/00; A61P19/02; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C07K14/525; C07K16/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/28; C12N15/85
Domestic Patent References:
| JP2011528562A | ||||
| JP2014504301A | ||||
| JP2008537941A | ||||
| JP2018533947A | ||||
| JP2018533948A |
Other References:
J Biol Chem. 2005 Dec 16, vol. 280, no. 50, pp. 41472-41481
Attorney, Agent or Firm:
Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe
Shinya Mihiro
Tatsuhiko Abe
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