Title:
SLOW-RELEASABLE BIOACTIVE AND BIOABSORBABLE ORGANIC-INORGANIC COMPOUNDED MATERIAL HAVING BONE INDUCING OR BONE CONDUCTING FUNCTION
Document Type and Number:
Japanese Patent JP3692390
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To give a bone inducing or bone conductive function having well balanced properties among flexibility, strength, elastic modulus, productivity, reproducibility and shaping processability by improving brittleness, shaping processability and productivity of bioactive calcium phosphate.
SOLUTION: This compounded material comprises a structural unit originated from lactic acid and a polyester structural unit originated from a dicarboxylic acid and a diol, and it comprises 2-60wt.% of the lactic acid-based polyester having a weight average molecular weight of 20,000 to 400,000 and calcium phosphate and has a ratio of the lactic acid-based polyester to calcium phosphate of 1/99 to 50/50 by weight. Further, by making the lactic acid based- polyester contain a chelating agent and/or a structural unit originated from an acidic phosphate, a medicinal slow releasability having bone inducing or conducting function improved in stability on blending and shaping processing is attained.
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Inventors:
Nori Shikata
Kakizawa Houri
Junzo Tanaka
Suetsugu Ning
Masaki Kikuchi
Kakizawa Houri
Junzo Tanaka
Suetsugu Ning
Masaki Kikuchi
Application Number:
JP19377196A
Publication Date:
September 07, 2005
Filing Date:
July 23, 1996
Export Citation:
Assignee:
National Institute for Materials Science
International Classes:
A61K9/00; A61K6/00; A61K6/891; A61K9/70; A61K47/34; A61L27/00; C08G63/08; C08G63/16; C08J3/20; C08K3/32; C08L67/00; C08L67/04; (IPC1-7): A61L27/00
Domestic Patent References:
| JP4279520A | ||||
| JP6298639A | ||||
| JP63038463A | ||||
| JP7118513A |
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Shigeo Naruse
Takashi Watanabe
Shigeo Naruse