Title:
SMALL MOLECULE INHIBITORS OF NECROPTOSIS
Document Type and Number:
Japanese Patent JP2015061853
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compounds that inhibit tumor necrosis factor alpha (TNF-α)-induced necroptosis and are effective in treatment of conditions such as a neurodegenerative disease of the central or peripheral nervous system, the result of retinal neuronal cell death, the result of cell death of cardiac muscle, the result of cell death of cells of the immune system, stroke, and a liver disease.SOLUTION: There are provided 5-membered heterocyclic compounds having structures represented by formula (VI-A) or formula (VI-B).
Inventors:
YUAN JUNYING
EMILY S HSU
EMILY S HSU
Application Number:
JP2014230271A
Publication Date:
April 02, 2015
Filing Date:
November 13, 2014
Export Citation:
Assignee:
HARVARD COLLEGE
International Classes:
C07D233/72; A61K31/404; A61K31/4166; A61K31/4178; A61P1/04; A61P1/14; A61P1/16; A61P1/18; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P19/08; A61P21/04; A61P25/00; A61P25/02; A61P25/28; A61P27/02; A61P31/04; A61P31/12; A61P35/00; A61P37/02; A61P37/06; C07D403/06; C07D405/06
Domestic Patent References:
| JPH05262728A | 1993-10-12 | |||
| JP2007508349A | 2007-04-05 | |||
| JP2011507910A | 2011-03-10 |
Foreign References:
| WO2007047146A2 | 2007-04-26 |
Other References:
LEWIS, R. T. ET AL.: "Tryptophan-Derived NK1 Antagonists: Conformationally Constrained Heterocyclic Bioisosteres of the Es", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 6, JPN6015046674, 1995, pages 923 - 933, XP055234130, ISSN: 0003200299, DOI: 10.1021/jm00006a011
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka