Title:
PTHrP由来の平滑筋増殖モジュレータ
Document Type and Number:
Japanese Patent JP2006508646
Kind Code:
A
Abstract:
The present invention relates to the use of mutants of parathyroid hormone-related protein, to treat disorders associated with smooth muscle cells, and to inhibit the cellular activation and proliferation thereof. The method can be employed in diverse tissues to effect therapeutic and prophylactic relief for disorders and diseases manifested by activation of smooth muscle that can lead to excessive smooth muscle proliferation. For example, where employed in the vasculature, the inventive method can be used to treat restenosis following angioplasty.
Inventors:
Stuart Andrew F.
FIATCH-Tesh Natalie
FIATCH-Tesh Natalie
Application Number:
JP2004529405A
Publication Date:
March 16, 2006
Filing Date:
August 13, 2003
Export Citation:
Assignee:
Vasculostatin LLC
International Classes:
C12N15/09; A61K31/7088; A61K35/76; A61K38/00; A61K38/29; A61K39/395; A61K48/00; A61L31/00; A61P1/16; A61P9/00; A61P9/10; A61P9/12; A61P11/08; A61P13/08; A61P13/10; A61P15/08; A61P43/00; C07K14/00; C07K14/575; C07K14/635; C07K16/18; C07K16/26; C07K16/46; C12N1/19; C12N1/21; C12N5/00; C12N5/10; C12N7/00; C12N15/00; C12N15/861; C12P21/02; C12Q1/68; G01N33/53; G01N33/74; C12P21/08; C12R1/93; A61B
Domestic Patent References:
| JP2000513201A | 2000-10-10 | |||
| JP3280021B2 | 2002-04-30 | |||
| JP2000513201A | 2000-10-10 | |||
| JP3280021B2 | 2002-04-30 |
Foreign References:
| US5605815A | 1997-02-25 | |||
| US5605815A | 1997-02-25 |
Other References:
JPN6009041733, Ｅｎｄｏｃｒｉｎｏｌｏｇｙ， １４２［９］ （２００１） ｐ．４０９６−４１０５
JPN6009041732, Ａｍ Ｊ Ｐｈｙｓｉｏｌ Ｅｎｄｏｃｒｉｎｏｌ Ｍｅｔａｂ．， ２７９ （２０００） ｐ．Ｅ６０−Ｅ６７
JPN6009041726, Ａｍ Ｊ Ｐｈｙｓｉｏｌ Ｃｅｌｌ Ｐｈｙｓｉｏｌ．， ２８３ （２００２ Ｊｕｌｙ） ｐ．Ｃ１９３−Ｃ２０３
JPN6009041724, Ｊ Ｃｅｌｌ Ｂｉｏｃｈｅｍ．， ７０ （１９９８） ｐ．１９３−１９９
JPN6009041721, Ｍｏｌ Ｃｅｌｌ Ｂｉｏｌ．， １５［８］ （１９９５） ｐ．４０６４−４０７５
JPN6009041718, ＰＮＡＳ．， ９４ （１９９７） ｐ．１３６３０−１３６３５
JPN6009041728, ホルモンと臨床， ４６［春季増刊号］ （１９９８） ｐ．２０４−２１１
JPN6009041730, Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ， １５２［１］ （２０００） ｐ．９７−１０５
JPN6009041732, Ａｍ Ｊ Ｐｈｙｓｉｏｌ Ｅｎｄｏｃｒｉｎｏｌ Ｍｅｔａｂ．， ２７９ （２０００） ｐ．Ｅ６０−Ｅ６７
JPN6009041726, Ａｍ Ｊ Ｐｈｙｓｉｏｌ Ｃｅｌｌ Ｐｈｙｓｉｏｌ．， ２８３ （２００２ Ｊｕｌｙ） ｐ．Ｃ１９３−Ｃ２０３
JPN6009041724, Ｊ Ｃｅｌｌ Ｂｉｏｃｈｅｍ．， ７０ （１９９８） ｐ．１９３−１９９
JPN6009041721, Ｍｏｌ Ｃｅｌｌ Ｂｉｏｌ．， １５［８］ （１９９５） ｐ．４０６４−４０７５
JPN6009041718, ＰＮＡＳ．， ９４ （１９９７） ｐ．１３６３０−１３６３５
JPN6009041728, ホルモンと臨床， ４６［春季増刊号］ （１９９８） ｐ．２０４−２１１
JPN6009041730, Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ， １５２［１］ （２０００） ｐ．９７−１０５
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi