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Title:
SOLID CATALYST FOR ASYMMETRIC MICHAEL ADDITION REACTION
Document Type and Number:
Japanese Patent JP2008246401
Kind Code:
A
Abstract:

To provide a solid catalyst for asymmetric Michael addition reaction easily separated from a product, enhanced in optical purity and prepared in an industrially inexpensive manner, and a manufacturing method of an optically active Michael addition product by the asymmetric Michael addition reaction of a 1, 3-dicarbonyl compound and an enone compound using the solid catalyst for asymmetric Michael addition reaction.

The solid catalyst for asymmetric Michael addition reaction is constituted by fixing lanthanide and an asymmetric carboxylic acid on a carrier comprising hydroxyapatite represented by the general formula (I): Ca10-z(HPO4)z(PO4)6-z(OH)2-z*nH2O and/or fluoroapatite represented by the general formula (II): Ca10-y(HPO4)y(PO4)6-yF2-y*nH2O both of which are preliminarily treated with the asymmetric carboxylic acid and produced by adding hydroxyapatite represented by the general formula (I) and/or fluoroapatite represented by the general formula (II), both of which are preliminarily treated with the asymmetric carboxylic acid to a solution, which is prepared by dissolving a salt of lanthanide and the asymmetric carboxylic acid in a solvent, to stirr the resulting solution to bond lanthanide to oxygen of phosphoric acid by the ion exchange with calcium of hydroxyapatite and/or fluoroapatite. The manufacturing method of the optically active Michael addition product is characterized in that the 1, 3-dicarbonyl compound and the enone compound are reacted in the presence of the solid catalyst for asymmetric Michael addition reaction.


Inventors:
Kaneda, Kiyoomi
Ueno, Shinji
Application Number:
JP2007000092285
Publication Date:
October 16, 2008
Filing Date:
March 30, 2007
Export Citation:
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Assignee:
NE CHEMCAT CORP
International Classes:
B01J31/26; C07C51/353; C07C62/24; C07C67/347; C07C69/757; C07B53/00; C07B61/00
Attorney, Agent or Firm:
岩見谷 周志