Title:
シアル酸誘導体を含む固体分散体
Document Type and Number:
Japanese Patent JP4427900
Kind Code:
B2
Abstract:
The invention provides a medicament comprising a sialic acid derivative represented by the following formula and have superior solubility and absorbability. A solid dispersion comprising a water soluble macromolecule such as hydroxypropylmethylcellulose and a sialic acid derivative dispersed in the water-soluble macromolecule and represented by the following formula (I): R<1> represents a steroid compound residue; R<2> represents hydrogen atom or a C1-C4 alkyl group, R<3> represents a C1-C15 alkyl group etc.; X represents an oxygen atom or a sulfur atom, e.g., 3 alpha - N-(5-acetamido-3,5-dideoxy-2-O-methyl- alpha -D-glycero-D-galacto-2-noneuropyranosonyl)aminocholestane.
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Inventors:
Takeshi Inamori
Chikako Takahashi
Yoshiyuki Fujimura
Chikako Takahashi
Yoshiyuki Fujimura
Application Number:
JP2000543487A
Publication Date:
March 10, 2010
Filing Date:
April 09, 1999
Export Citation:
Assignee:
Mitsubishi Chemical Corporation
International Classes:
C07J17/00; A61K31/58; A61K31/70; A61K31/7008; C07J
Domestic Patent References:
| JP9002957A | ||||
| JP9002956A | ||||
| JP63063697A | ||||
| JP62209094A | ||||
| JP7228592A |
Foreign References:
| WO1997000885A1 |
Other References:
CHIOU, W. L.,Pharmaceutical Applications of Solid Dispersion Systems,Journal of Pharmaceutical Sciences,1971年,60(9),p. 1281-1302
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes
Masazumi Imamura
Toshio Shiozawa
Junji Kamata
Masazumi Imamura
Toshio Shiozawa
Junji Kamata