Title:
ＦＧＦＲ阻害剤の固体形態及びその調製プロセス
Document Type and Number:
Japanese Patent JP2021523121
Kind Code:
A
Abstract:
本開示は、がんなどのＦＧＦＲ関連疾患または媒介疾患の治療に有用である、３−（２，６−ジフルオロ−３，５−ジメトキシフェニル）−１−エチル−８−（モルホリン−４−イル−メチル）−１，３，４，７−テトラヒドロ−２Ｈ−ピロロ［３’，２’：５，６］ピリド［４，３−ｄ］ピリミジン−２−オン、その固体形態及び多形体、その調製方法、及びその調製における中間体に関する。
Inventors:
Timothy Sea Burn
Philip Sea Liu
William Fryce
John Gian Zia
Min Tao
Denjin One
Jiachen Chow
Lee Chun
Philip Sea Liu
William Fryce
John Gian Zia
Min Tao
Denjin One
Jiachen Chow
Lee Chun
Application Number:
JP2020561741A
Publication Date:
September 02, 2021
Filing Date:
May 03, 2019
Export Citation:
Assignee:
INCYTE CORPORATION
International Classes:
C07D471/14; A61K9/20; A61K31/5377; A61P35/00; A61P35/04
Domestic Patent References:
| JP2015521600A | 2015-07-30 | |||
| JP2009536959A | 2009-10-22 |
Other References:
PHARM TECH JAPAN, vol. 18, no. 10, JPN7014002019, 2002, pages 81 - 96, ISSN: 0005016967
CAIRA, MINO R.: "Crystalline Polymorphism of Organic Compounds", TOPICS IN CURRENT CHEMISTRY, vol. 198, JPN7023001155, 1998, pages 163 - 208, XP008166276, ISSN: 0005016968, DOI: 10.1007/3-540-69178-2_5
HEINRICH, T. ET AL.: "Fragment-Based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridi", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56(3), JPN6023011502, 2013, pages 1160 - 1170, ISSN: 0005016969
CAIRA, MINO R.: "Crystalline Polymorphism of Organic Compounds", TOPICS IN CURRENT CHEMISTRY, vol. 198, JPN7023001155, 1998, pages 163 - 208, XP008166276, ISSN: 0005016968, DOI: 10.1007/3-540-69178-2_5
HEINRICH, T. ET AL.: "Fragment-Based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridi", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56(3), JPN6023011502, 2013, pages 1160 - 1170, ISSN: 0005016969
Attorney, Agent or Firm:
Michiko Matsutani
Yasushi Ochiai
Yasushi Ochiai