Title:
可溶性エフェクターBR43x2およびその使用方法
Document Type and Number:
Japanese Patent JP5021117
Kind Code:
B2
Abstract:
There is provided a fusion protein consisting of a first portion and a second portion joined by a peptide bond, wherein said first portion consists of an amino acid sequence selected from: (i) amino acid residues 25-104 of SEQ ID NO: 6; (ii) amino acid residues 34-66 of SEQ ID NO: 6; (iii) amino acid residues 71-104 of SEQ ID NO: 6; and (iv) amino acid residues 34-66 and 71-104 of SEQ ID NO: 6; and said second portion is an immunoglobulin heavy chain constant region. There is also provided an antibody or antibody fragment that specifically binds to a polypeptide selected from SEQ ID NO: 59 or SEQ ID N: 60. There is also provided an antibody or antibody fragment that specifically binds to a ztnf4 polypeptide, for use in treating systemic lupus erythematosus in a mammal.
Inventors:
Gross, Jane A.
Shu, Wen Feng
Madden, Karen
Yee, David Pee.
Shu, Wen Feng
Madden, Karen
Yee, David Pee.
Application Number:
JP2000592413A
Publication Date:
September 05, 2012
Filing Date:
January 07, 2000
Export Citation:
Assignee:
Zymogenetics, Incorporated
International Classes:
A61K38/00; A61K38/17; C12N15/09; A61K39/395; A61P3/10; A61P7/02; A61P7/06; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P19/02; A61P21/04; A61P25/28; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C07K14/705; C07K14/715; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/08
Foreign References:
| WO1998018921A1 | 1998-05-07 | |||
| EP0869180A1 | 1998-10-07 | |||
| WO1998039361A1 | 1998-09-11 |
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji