Title:
治療薬送達のための可溶性疎水性コア担体組成物、およびその製造・使用方法
Document Type and Number:
Japanese Patent JP5878912
Kind Code:
B2
Abstract:
The present invention relates to a soluble hydrophobic-core carrier composition comprising (i) a linear polymeric backbone; (ii) a plurality of hydrophilic polymeric protective chains covalently linked and pendant to the polymeric backbone and (iii) at least one hydrophobic moiety covalently linked and pendant to the polymeric backbone. In certain embodiments, the weight ratio of hydrophilic protective chains to hydrophobic moieties in the carrier is at least 15:1. In other embodiments, at least 90% of the residues of the polymeric backbone are coupled to a hydrophilic polymeric protective chain or a hydrophobic moiety. In other embodiments, the composition further comprises (iv) a hydrophobic load molecule dissociably linked to the hydrophobic moiety of the carrier.
Inventors:
Gerald M. Castillo
Elijah M. Borotin
Elijah M. Borotin
Application Number:
JP2013259956A
Publication Date:
March 08, 2016
Filing Date:
December 17, 2013
Export Citation:
Assignee:
Pharmaine Corporation
International Classes:
A61K47/34; A61K38/00; A61K38/26; A61K45/00; A61K47/36; A61K47/42; A61K47/48
Domestic Patent References:
| JP2002194080A | ||||
| JP2006503933A | ||||
| JP8501097A |
Foreign References:
| US20070141145 | ||||
| WO2005115492A1 | ||||
| US6576254 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto